ARMT1 Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response. Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily. Note: This description may include information from UniProtKB.
Chromosomal Location of human Ortholog: 6q25.1
Cellular Component: 
Molecular Function:  enzyme binding; fructose 6-phosphate aldolase activity; fructose-1-phosphatase activity; metal ion binding; phosphatase activity; protein binding; protein carboxyl O-methyltransferase activity; protein-glutamate O-methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity
Biological Process:  cellular response to DNA damage stimulus; methylation; protein methylation; regulation of response to DNA damage stimulus
Reference #:  Q9H993 (UniProtKB)
Alt. Names/Synonyms: acidic residue methyltransferase 1; ARMT1; C6orf211; CF211; Damage-control phosphatase ARMT1; DKFZp566I174; FLJ12910; LOC79624; Protein-glutamate O-methyltransferase; Sugar phosphate phosphatase ARMT1; UPF0364 protein C6orf211
Gene Symbols: ARMT1
Molecular weight: 51,172 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene