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ARMT1
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response. Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 6q25.1 |
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Cellular Component:
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Molecular Function:
enzyme binding; fructose 6-phosphate aldolase activity; fructose-1-phosphatase activity; metal ion binding; phosphatase activity; protein binding; protein carboxyl O-methyltransferase activity; protein-glutamate O-methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity
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Biological Process:
DNA damage response; methylation
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Reference #:
Q9H993
(UniProtKB)
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Alt. Names/Synonyms: acidic residue methyltransferase 1; ARMT1; C6orf211; CF211; Damage-control phosphatase ARMT1; DKFZp566I174; FLJ12910; LOC79624; Protein-glutamate O-methyltransferase; Sugar phosphate phosphatase ARMT1; UPF0364 protein C6orf211
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Gene Symbols: ARMT1
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Molecular weight:
51,172 Da
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Basal Isoelectric point:
5.48
Predict pI for various phosphorylation states
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