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CRP
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentraxin family. Found in plasma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 1q23.2 |
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Cellular Component:
extracellular region; extracellular space
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Molecular Function:
calcium ion binding; choline binding; complement component C1q complex binding; identical protein binding; low-density lipoprotein particle binding; low-density lipoprotein particle receptor binding; protein binding; virion binding
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Biological Process:
acute-phase response; defense response to Gram-positive bacterium; inflammatory response; innate immune response; negative regulation of lipid storage; negative regulation of macrophage derived foam cell differentiation; negative regulation of mononuclear cell proliferation; opsonization; positive regulation of gene expression; positive regulation of superoxide anion generation; regulation of interleukin-8 production; vasoconstriction
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Reference #:
P02741
(UniProtKB)
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Alt. Names/Synonyms: C Reactive Protein; C-reactive protein; C-reactive protein(1-205); C-reactive protein, pentraxin-related; CRP; MGC149895; MGC88244; pentraxin 1; PTX1
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Gene Symbols: CRP
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Molecular weight:
25,039 Da
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Basal Isoelectric point:
5.45
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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