IGFBP3 IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Expressed by most tissues. Present in plasma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 7p12.3
Cellular Component:  endoplasmic reticulum lumen; extracellular region; extracellular space; insulin-like growth factor binding protein complex; insulin-like growth factor ternary complex; nucleus
Molecular Function:  insulin-like growth factor binding; insulin-like growth factor I binding; metal ion binding; protein binding; protein tyrosine phosphatase activator activity
Biological Process:  apoptotic process; cellular protein metabolic process; negative regulation of cell proliferation; negative regulation of protein phosphorylation; negative regulation of signal transduction; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; osteoblast differentiation; positive regulation of apoptotic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of myoblast differentiation; post-translational protein modification; protein phosphorylation; regulation of apoptotic process; regulation of cell growth; regulation of glucose metabolic process; regulation of phosphoprotein phosphatase activity; type B pancreatic cell proliferation
Reference #:  P17936 (UniProtKB)
Alt. Names/Synonyms: acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP-53; growth hormone-dependent binding protein; IBP-3; IBP3; IGF-binding protein 3; IGFBP-3; IGFBP3; insulin like growth factor binding protein 3; insulin-like growth factor binding protein 3; Insulin-like growth factor-binding protein 3
Gene Symbols: IGFBP3
Molecular weight: 31,674 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein