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BRIP1
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Belongs to the DEAD box helicase family. DEAH subfamily. Ubiquitously expressed, with highest levels in testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.4.13; Helicase; Oncoprotein |
| Chromosomal Location of human Ortholog: 17q23.2 |
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Cellular Component:
BRCA1-B complex; cytoplasm; nuclear membrane; nucleoplasm; nucleus
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Molecular Function:
4 iron, 4 sulfur cluster binding; 5'-3' DNA helicase activity; ATP binding; ATP hydrolysis activity; chromatin binding; DNA binding; DNA helicase activity; metal ion binding; protein binding; RNA helicase activity
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Biological Process:
cellular response to angiotensin; cellular response to hypoxia; cellular response to vitamin; chiasma assembly; DNA damage checkpoint signaling; DNA duplex unwinding; DNA repair; double-strand break repair; double-strand break repair involved in meiotic recombination; homologous recombination; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination; negative regulation of cell population proliferation; negative regulation of gene expression; nucleotide-excision repair; regulation of transcription by RNA polymerase II; response to toxic substance; seminiferous tubule development; spermatid development; spermatogonial cell division
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Disease: Breast Cancer; Fanconi Anemia, Complementation Group J
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Reference #:
Q9BX63
(UniProtKB)
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Alt. Names/Synonyms: ATP-dependent RNA helicase BRIP1; BACH1; BRCA1 interacting protein C-terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1/BRCA2-associated helicase 1; BRIP1; FANCJ; Fanconi anemia group J protein; FLJ90232; MGC126521; MGC126523; OF; Protein FACJ
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Gene Symbols: BRIP1
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Molecular weight:
140,868 Da
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Basal Isoelectric point:
6.49
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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