BRIP1 a DNA-dependent ATPase and DNA helicase required for the maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Binds directly to the BRCT domains of BRCA1. Defects in BRIP1 cause of susceptibility to breast cancer and Fanconi anemia. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Belongs to the DEAD box helicase family, DEAH subfamily. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.13; Helicase; Oncoprotein
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component:  cytoplasm; nuclear membrane; nucleoplasm; nucleus
Molecular Function:  4 iron, 4 sulfur cluster binding; ATP binding; ATP-dependent DNA helicase activity; chromatin binding; DNA binding; metal ion binding; protein binding
Biological Process:  cellular response to angiotensin; cellular response to hypoxia; cellular response to vitamin; chiasma formation; DNA damage checkpoint; DNA duplex unwinding; DNA replication; double-strand break repair; double-strand break repair involved in meiotic recombination; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination; negative regulation of cell proliferation; negative regulation of gene expression; nucleotide-excision repair; regulation of transcription from RNA polymerase II promoter; response to toxin; seminiferous tubule development; spermatid development; spermatogonial cell division
Disease: Breast Cancer; Fanconi Anemia, Complementation Group J
Reference #:  Q9BX63 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase BRIP1; BACH1; BRCA1 interacting protein C-terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRIP1; FANCJ; Fanconi anemia group J protein; FLJ90232; MGC126521; MGC126523; OF; Protein FACJ
Gene Symbols: BRIP1
Molecular weight: 140,868 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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BRIP1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene