PITPNM1 Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component:  cell body; cleavage furrow; cytoplasmic ribonucleoprotein granule; cytosol; endoplasmic reticulum membrane; Golgi cisterna membrane; lipid droplet; membrane; microtubule organizing center; midbody
Molecular Function:  calcium ion binding; phosphatidic acid binding; phosphatidylcholine binding; phosphatidylinositol binding; phosphatidylinositol transporter activity; protein binding; receptor tyrosine kinase binding
Biological Process:  brain development; lipid metabolic process; phosphatidylinositol biosynthetic process; phospholipid transport; phototransduction; protein transport
Reference #:  O00562 (UniProtKB)
Alt. Names/Synonyms: DRES9; Drosophila retinal degeneration B homolog; FLJ44997; Membrane-associated phosphatidylinositol transfer protein 1; NIR-2; NIR2; phosphatidylinositol transfer protein membrane associated 1; Phosphatidylinositol transfer protein, membrane-associated 1; PITM1; PITPNM; PITPnm 1; PITPNM1; Pyk2 N-terminal domain-interacting receptor 2; Rd9; RDGB; RDGB1; RDGBA; RDGBA1; retinal degeneration B alpha 1
Gene Symbols: PITPNM1
Molecular weight: 134,848 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
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PITPNM1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein