XRCC1 Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity. Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level). Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 7 A3|7 11.42 cM
Cellular Component:  ERCC4-ERCC1 complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleolus; nucleus
Molecular Function:  damaged DNA binding; enzyme binding; oxidized DNA binding
Biological Process:  base-excision repair; cellular response to DNA damage stimulus; cerebellum morphogenesis; DNA repair; double-strand break repair via nonhomologous end joining; hippocampus development; negative regulation of protection from non-homologous end joining at telomere; negative regulation of protein ADP-ribosylation; positive regulation of DNA ligase activity; positive regulation of single strand break repair; replication-born double-strand break repair via sister chromatid exchange; response to hydroperoxide; single strand break repair; telomeric DNA-containing double minutes formation; voluntary musculoskeletal movement
Reference #:  Q60596 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein XRCC1; MGC102556; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1; Xrcc-; Xrcc-1; Xrcc1
Gene Symbols: Xrcc1
Molecular weight: 68,971 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene