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XRCC1
Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity. Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage |
| Chromosomal Location of human Ortholog: 19q13.31 |
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Cellular Component:
chromatin; chromosome, telomeric region; ERCC4-ERCC1 complex; nucleolus; nucleoplasm; nucleus; site of DNA damage
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Molecular Function:
3' overhang single-stranded DNA endodeoxyribonuclease activity; enzyme binding; oxidized DNA binding; poly-ADP-D-ribose binding; protein binding
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Biological Process:
base-excision repair; cerebellum morphogenesis; double-strand break repair via nonhomologous end joining; hippocampus development; negative regulation of protection from non-homologous end joining at telomere; negative regulation of protein ADP-ribosylation; positive regulation of DNA ligase activity; positive regulation of single strand break repair; replication-born double-strand break repair via sister chromatid exchange; response to hydroperoxide; response to hypoxia; response to organic substance; response to xenobiotic stimulus; single strand break repair; telomeric DNA-containing double minutes formation; voluntary musculoskeletal movement
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Disease: Spinocerebellar Ataxia, Autosomal Recessive 26
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Reference #:
P18887
(UniProtKB)
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Alt. Names/Synonyms: DNA repair protein XRCC1; RCC; SCAR26; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross complementing 1; X-ray repair cross complementing protein 1; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster; XRCC1
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Gene Symbols: XRCC1
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Molecular weight:
69,498 Da
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Basal Isoelectric point:
5.93
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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