TUBB8 Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation. Belongs to the tubulin family. Expressed at a high level in oocytes, at different stages of development. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of human Ortholog: 10p15.3
Cellular Component:  cytoplasm; intercellular bridge; meiotic spindle; microtubule; microtubule cytoskeleton; mitotic spindle
Molecular Function:  GTP binding; GTPase activity; metal ion binding; structural constituent of cytoskeleton
Biological Process:  microtubule cytoskeleton organization; mitotic cell cycle; oocyte maturation; spindle assembly involved in female meiosis
Disease: Oocyte Maturation Defect 2
Reference #:  Q3ZCM7 (UniProtKB)
Alt. Names/Synonyms: bA631M21.2; FLJ40100; HSA10p15 beta-tubulin 4Q; OOMD; OOMD2; TBB8; TUBB8; Tubulin beta 8 class VIII; Tubulin beta-8 chain; tubulin, beta 8
Gene Symbols: TUBB8
Molecular weight: 49,776 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene