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TUBB8
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation. Belongs to the tubulin family. Expressed at a high level in oocytes, at different stages of development. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of human Ortholog: 10p15.3 |
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Cellular Component:
cytoplasm; intercellular bridge; meiotic spindle; microtubule; microtubule cytoskeleton; mitotic spindle
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Molecular Function:
GTP binding; GTPase activity; metal ion binding; structural constituent of cytoskeleton
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Biological Process:
microtubule cytoskeleton organization; mitotic cell cycle; oocyte maturation; spindle assembly involved in female meiosis
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Disease: Oocyte Maturation Defect 2
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Reference #:
Q3ZCM7
(UniProtKB)
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Alt. Names/Synonyms: bA631M21.2; FLJ40100; HSA10p15 beta-tubulin 4Q; OOMD; OOMD2; TBB8; TUBB8; Tubulin beta 8 class VIII; Tubulin beta-8 chain; tubulin, beta 8
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Gene Symbols: TUBB8
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Molecular weight:
49,776 Da
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Basal Isoelectric point:
4.79
Predict pI for various phosphorylation states
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