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SOS1
Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity. Expressed in gingival tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 17 E3|17 50.67 cM |
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Cellular Component:
cytoplasm; cytosol; GTPase complex; neuronal cell body; plasma membrane
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Molecular Function:
epidermal growth factor receptor binding; guanyl-nucleotide exchange factor activity; protein binding; protein heterodimerization activity; SH3 domain binding
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Biological Process:
B cell homeostasis; B cell receptor signaling pathway; blood vessel morphogenesis; cardiac atrium morphogenesis; epidermal growth factor receptor signaling pathway; eyelid development in camera-type eye; fibroblast growth factor receptor signaling pathway; hair follicle development; heart morphogenesis; heart trabecula morphogenesis; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; lymphocyte homeostasis; midbrain morphogenesis; multicellular organism growth; neurotrophin TRK receptor signaling pathway; pericardium morphogenesis; positive regulation of GTPase activity; positive regulation of Ras protein signal transduction; positive regulation of small GTPase mediated signal transduction; Ras protein signal transduction; regulation of cell population proliferation; regulation of MAP kinase activity; regulation of pro-B cell differentiation; regulation of T cell differentiation in thymus; regulation of T cell proliferation; regulation of transcription by RNA polymerase II; response to ischemia; roof of mouth development; small GTPase mediated signal transduction; vitellogenesis
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Reference #:
Q62245
(UniProtKB)
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Alt. Names/Synonyms: 4430401P03Rik; 9630010N06; AI449023; guanine nucleotide releasing factor; mSOS-1; ras guanine exchange factor; Son of sevenless homolog 1; son of sevenless homolog 1 (Drosophila); son-of-sevenless 1; SOS Ras/Rac guanine nucleotide exchange factor 1; SOS-1; Sos1
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Gene Symbols: Sos1
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Molecular weight:
150,883 Da
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Basal Isoelectric point:
6.43
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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ErbB/HER Signaling
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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Insulin Receptor Signaling
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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