VAMP2 Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Belongs to the synaptobrevin family. Nervous system and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of mouse Ortholog: 11|11 B3
Cellular Component:  clathrin-coated vesicle; clathrin-sculpted glutamate transport vesicle membrane; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; membrane; neuron projection terminus; perinuclear region of cytoplasm; plasma membrane; secretory granule; secretory granule membrane; SNARE complex; storage vacuole; synapse; synaptic vesicle; synaptic vesicle membrane; synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex; trans-Golgi network; vesicle; zymogen granule membrane
Molecular Function:  calcium-dependent protein binding; calmodulin binding; identical protein binding; lipid binding; molecular adaptor activity; myosin binding; phospholipid binding; protein binding; protein-containing complex binding; SNAP receptor activity; SNARE binding; syntaxin binding; syntaxin-1 binding; transmembrane transporter binding
Biological Process:  calcium-ion regulated exocytosis; cellular response to insulin stimulus; eosinophil degranulation; establishment of localization in cell; exocytic insertion of neurotransmitter receptor to postsynaptic membrane; Golgi to plasma membrane protein transport; hormone secretion; long-term synaptic potentiation; membrane fusion; positive regulation of intracellular protein transport; protein-containing complex assembly; regulated exocytosis; regulation of calcium ion-dependent exocytosis; regulation of delayed rectifier potassium channel activity; regulation of exocytosis; regulation of synaptic vesicle recycling; regulation of vesicle-mediated transport; response to glucose; SNARE complex assembly; synaptic vesicle docking; synaptic vesicle endocytosis; synaptic vesicle exocytosis; vesicle fusion; vesicle-mediated transport
Reference #:  P63044 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000006177; Syb; Syb-; Syb-2; Syb2; sybII; synaptobrevin II; synaptobrevin-2; VAMP-2; Vamp2; vesicle-associated membrane 2; Vesicle-associated membrane protein 2
Gene Symbols: Vamp2
Molecular weight: 12,691 Da
Basal Isoelectric point: 7.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein