KIDINS220 Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 12|12 A1.3
Cellular Component:  late endosome; protein-containing complex
Molecular Function:  PDZ domain binding; protein kinase binding; protein kinase regulator activity
Biological Process:  cellular response to nerve growth factor stimulus; dendrite morphogenesis; in utero embryonic development; nerve growth factor signaling pathway; positive regulation of neuron projection development
Reference #:  E9Q9B7 (UniProtKB)
Alt. Names/Synonyms: 3110039L19Rik; AI194387; AI316525; C330002I19Rik; Kidins220; Kinase D-interacting substrate 220; kinase D-interacting substrate of 220 kDa; mKIAA1250; MKIAA1250 protein
Gene Symbols: Kidins220
Molecular weight: 199,184 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene