KIDINS220 Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component:  cytosol; integral component of membrane; late endosome; protein-containing complex
Molecular Function:  PDZ domain binding
Biological Process:  activation of MAPKK activity; cellular response to nerve growth factor stimulus; dendrite morphogenesis; in utero embryonic development; nerve growth factor signaling pathway; positive regulation of neuron projection development
Disease: Spastic Paraplegia, Intellectual Disability, Nystagmus, And Obesity
Reference #:  Q9ULH0 (UniProtKB)
Alt. Names/Synonyms: ankyrin repeat-rich membrane spanning; Ankyrin repeat-rich membrane-spanning protein; ARMS; KDIS; KIAA1250; KIDINS220; Kinase D-interacting substrate of 220 kDa; kinase D-interacting substrate, 220kDa; MGC163482
Gene Symbols: KIDINS220
Molecular weight: 196,542 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene