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FOXM1 iso2
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 12p13.33 |
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Cellular Component:
chromatin; nucleoplasm; nucleus
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Molecular Function:
DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein kinase binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding
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Biological Process:
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA repair; G2/M transition of mitotic cell cycle; negative regulation of DNA-templated transcription; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair; positive regulation of transcription by RNA polymerase II; regulation of cell cycle; regulation of cell population proliferation; regulation of Ras protein signal transduction; regulation of reactive oxygen species metabolic process; regulation of transcription by RNA polymerase II
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Reference #:
Q08050-2
(UniProtKB)
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Alt. Names/Synonyms: FKHL16; forkhead box M1; forkhead box M1-D; Forkhead box protein M1; Forkhead, drosophila, homolog-like 16; forkhead-like 16; Forkhead-related protein FKHL16; FOXM1; FOXM1 iso2; FOXM1A; FOXM1B; FOXM1C; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HFH11; HNF-3; HNF-3/fork-head homolog 11; INS-1; M-phase phosphoprotein 2; MPHOSPH2; MPM-2 reactive phosphoprotein 2; MPP-2; MPP2; PIG29; TGT3; Transcription factor Trident; TRIDENT; WIN; Winged-helix factor from INS-1 cells
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Gene Symbols: FOXM1
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Molecular weight:
82,685 Da
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Basal Isoelectric point:
8.57
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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