PTPN3 May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of mouse Ortholog: 4 B3|4 31.66 cM
Cellular Component:  cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; membrane; plasma membrane
Molecular Function:  ATPase binding; cytoskeletal protein binding; hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; phosphotyrosine residue binding; protein tyrosine phosphatase activity; sodium channel regulator activity
Biological Process:  dephosphorylation; negative regulation of membrane protein ectodomain proteolysis; negative regulation of mitotic cell cycle; protein dephosphorylation; regulation of membrane depolarization during action potential; regulation of sodium ion transmembrane transporter activity
Reference #:  A2ALK8 (UniProtKB)
Alt. Names/Synonyms: 9530011I20Rik; protein tyrosine phosphatase, non-receptor type 3; protein-tyrosine phosphatase H1; PTN3; PTP-; PTP-H1; PTPCL; Ptpn3; Tyrosine-protein phosphatase non-receptor type 3
Gene Symbols: Ptpn3
Molecular weight: 103,896 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene