IREB1 Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. Belongs to the aconitase/IPM isomerase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC; Endoplasmic reticulum; Lyase; RNA-binding; Translation
Chromosomal Location of human Ortholog: 9p21.1
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; mitochondrion
Molecular Function:  3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity; iron-responsive element binding; metal ion binding; protein binding; RNA binding
Biological Process:  cellular iron ion homeostasis; citrate metabolic process; intestinal absorption; post-embryonic development; regulation of translation; response to iron(II) ion
Reference #:  P21399 (UniProtKB)
Alt. Names/Synonyms: ACO1; ACOC; Aconitase; aconitase 1; aconitase 1, soluble; aconitate hydratase; aconitate hydratase, cytoplasmic; ACONS; Citrate hydro-lyase; cytoplasmic aconitase; Cytoplasmic aconitate hydratase; cytosplasmic aconitase; epididymis luminal protein 60; epididymis secretory sperm binding protein; Ferritin repressor protein; HEL60; IRE-BP 1; IREB1; IREBP; IREBP1; Iron regulatory protein 1; iron-responsive element binding protein 1; Iron-responsive element-binding protein 1; IRP1; soluble aconitase
Gene Symbols: ACO1
Molecular weight: 98,399 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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