Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Biological Process: actin cytoskeleton reorganization; axonogenesis; cholecystokinin signaling pathway; eating behavior; feeding behavior; forebrain development; G protein-coupled receptor signaling pathway; gastric acid secretion; insulin secretion; neuron migration; pancreatic juice secretion; positive regulation of cytosolic calcium ion concentration; positive regulation of somatostatin secretion; reduction of food intake in response to dietary excess; regulation of calcium ion transport; regulation of hormone secretion; regulation of potassium ion transport; response to heat; response to starvation; signal transduction; temperature homeostasis