CCKAR Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 5 C1|5 29.52 cM
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; endosome; lysosome; membrane; nucleoplasm; plasma membrane; terminal bouton
Molecular Function:  cholecystokinin receptor activity; G protein-coupled receptor activity; peptide hormone binding
Biological Process:  actin cytoskeleton reorganization; axonogenesis; cholecystokinin signaling pathway; eating behavior; feeding behavior; forebrain development; G protein-coupled receptor signaling pathway; gastric acid secretion; insulin secretion; neuron migration; pancreatic juice secretion; positive regulation of cytosolic calcium ion concentration; positive regulation of somatostatin secretion; reduction of food intake in response to dietary excess; regulation of calcium ion transport; regulation of hormone secretion; regulation of potassium ion transport; response to heat; response to starvation; signal transduction; temperature homeostasis
Reference #:  O08786 (UniProtKB)
Alt. Names/Synonyms: AW106902; CCK-A receptor; CCK-AR; CCK1-R; Cckar; cholecystokinin A receptor; Cholecystokinin receptor type A; Cholecystokinin-1 receptor
Gene Symbols: Cckar
Molecular weight: 48,437 Da
Basal Isoelectric point: 9.32  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene