CCKAR Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 4p15.2
Cellular Component:  cytosol; membrane; nucleoplasm; plasma membrane
Molecular Function:  cholecystokinin receptor activity; peptide binding; peptide hormone binding
Biological Process:  axonogenesis; cellular response to hormone stimulus; cholecystokinin signaling pathway; forebrain development; G protein-coupled receptor signaling pathway; neuron migration; phospholipase C-activating G protein-coupled receptor signaling pathway; regulation of hormone secretion
Reference #:  P32238 (UniProtKB)
Alt. Names/Synonyms: CCK-A; CCK-A receptor; CCK-AR; CCK1-R; CCK1R; CCKAR; CCKRA; cholecystokinin A receptor; Cholecystokinin receptor type A; cholecystokinin type-A receptor; Cholecystokinin-1 receptor
Gene Symbols: CCKAR
Molecular weight: 47,841 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein