ADRA1B This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 11 B1.1|11 25.81 cM
Cellular Component:  cytoplasm; integral component of membrane; integral component of plasma membrane; intercalated disc; membrane; nuclear membrane; nucleus; plasma membrane; T-tubule
Molecular Function:  adrenergic receptor activity; alpha1-adrenergic receptor activity; G protein-coupled receptor activity; protein heterodimerization activity
Biological Process:  adenylate cyclase-activating adrenergic receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; adult heart development; behavioral response to cocaine; blood vessel remodeling; cell growth involved in cardiac muscle cell development; G protein-coupled receptor signaling pathway; glucose homeostasis; locomotory behavior; negative regulation of glycogen catabolic process; negative regulation of Rho protein signal transduction; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; organ growth; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of glycogen catabolic process; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of MAPK cascade; positive regulation of smooth muscle contraction; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of vasoconstriction; regulation of cardiac muscle contraction; regulation of muscle contraction; regulation of vasoconstriction; response to amphetamine; response to hormone; response to morphine; response to steroid hormone; signal transduction; vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure; visual learning
Reference #:  P97717 (UniProtKB)
Alt. Names/Synonyms: [a]1b; ADA1B; Adra1b; adrenergic receptor, alpha 1b; Alpha-1B adrenergic receptor; Alpha-1B adrenoceptor; Alpha-1B adrenoreceptor; alpha1B-adrenergic receptor; OTTMUSP00000005616
Gene Symbols: Adra1b
Molecular weight: 56,418 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene