ADRA1B This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q33.3
Cellular Component:  caveola; cytoplasm; nuclear membrane; nucleus; plasma membrane
Molecular Function:  protein binding; protein heterodimerization activity
Biological Process:  cell-cell signaling; G protein-coupled receptor signaling pathway; intracellular signal transduction; positive regulation of MAPK cascade; regulation of cardiac muscle contraction
Reference #:  P35368 (UniProtKB)
Alt. Names/Synonyms: ADA1B; ADRA1; ADRA1B; adrenergic, alpha-1B-, receptor; adrenoceptor alpha 1B; Alpha-1B adrenergic receptor; Alpha-1B adrenoceptor; Alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; ALPHA1BAR
Gene Symbols: ADRA1B
Molecular weight: 56,836 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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