ADCY2 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of mouse Ortholog: 13 B3|13 35.55 cM
Cellular Component:  cytoplasm; dendrite; membrane; membrane raft; plasma membrane; protein-containing complex
Molecular Function:  adenylate cyclase activity; adenylate cyclase binding; ATP binding; G-protein beta/gamma-subunit complex binding; lyase activity; magnesium ion binding; manganese ion binding; metal ion binding; nucleotide binding; phosphorus-oxygen lyase activity
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; cAMP-mediated signaling; cellular response to forskolin; cyclic nucleotide biosynthetic process; intracellular signal transduction
Reference #:  Q80TL1 (UniProtKB)
Alt. Names/Synonyms: Adcy2; adenylate cyclase 2; Adenylate cyclase type 2; Adenylate cyclase type II; Adenylyl cyclase 2; ATP pyrophosphate-lyase 2; Kiaa1060; MGC47193; mKIAA1060
Gene Symbols: Adcy2
Molecular weight: 123,270 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene