ADCY2 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 5p15.31
Cellular Component:  cytoplasm; dendrite; integral component of plasma membrane; membrane; membrane raft; plasma membrane
Molecular Function:  adenylate cyclase activity; adenylate cyclase binding; ATP binding; magnesium ion binding; manganese ion binding; protein heterodimerization activity
Biological Process:  activation of adenylate cyclase activity; activation of protein kinase A activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; cAMP-mediated signaling; cellular response to forskolin; cellular response to glucagon stimulus; G protein-coupled receptor signaling pathway; renal water homeostasis
Reference #:  Q08462 (UniProtKB)
Alt. Names/Synonyms: 3',5'-cyclic AMP synthetase; AC2; ADCY2; adenylate cyclase 2 (brain); adenylate cyclase II; Adenylate cyclase type 2; Adenylate cyclase type II; Adenylyl cyclase 2; ATP pyrophosphate-lyase 2; FLJ16822; FLJ45092; HBAC2; KIAA1060; MGC133314; type II adenylate cyclase
Gene Symbols: ADCY2
Molecular weight: 123,603 Da
Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB