CNR1
a Galpha-protein coupled receptor for endogenous cannabinoids. Ligands inclide anandamide, 2-AG, and phytocannabinoids such as THC. Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase, thus reducing cyclic AMP concentrations. Inhibits L-type Ca(2+) channel current. Has been reported to influence food intake, memory, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, and chronic pain. High-fat diet increases the hepatic levels of CNR1 ligand anandamide, but not that of 2-arachidonoylglycerol. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Isoform 2 and isoform 3 have altered ligand binding. Isoform 1 binds both 2-AG and anandamide, while Isoforms 2 and 3 only binds 2-AG with high affinity. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Molecular Function: cannabinoid receptor activity; G protein-coupled receptor activity; identical protein binding
Biological Process: adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; axonal fasciculation; cannabinoid signaling pathway; G protein-coupled receptor signaling pathway; glucose homeostasis; learning or memory; memory; negative regulation of action potential; negative regulation of blood pressure; negative regulation of dopamine secretion; negative regulation of fatty acid beta-oxidation; negative regulation of mast cell activation; negative regulation of monoatomic ion transport; negative regulation of nitric-oxide synthase activity; negative regulation of serotonin secretion; positive regulation of acute inflammatory response to antigenic stimulus; positive regulation of apoptotic process; positive regulation of blood pressure; positive regulation of fever generation; positive regulation of neuron projection development; regulation of feeding behavior; regulation of insulin secretion; regulation of lipid metabolic process; regulation of metabolic process; regulation of penile erection; regulation of presynaptic cytosolic calcium ion concentration; regulation of synaptic transmission, GABAergic; regulation of synaptic transmission, glutamatergic; response to cocaine; response to ethanol; response to lipopolysaccharide; response to nicotine; retrograde trans-synaptic signaling by endocannabinoid; signal transduction; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
