Plasminogen Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. Belongs to the peptidase S1 family. Plasminogen subfamily. Present in plasma and many other extracellular fluids. It is synthesized in the liver. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6q26
Cellular Component:  cell surface; extracellular region; extracellular space; extrinsic component of external side of plasma membrane; other organism cell membrane; plasma membrane; platelet alpha granule lumen
Molecular Function:  apolipoprotein binding; chaperone binding; endopeptidase activity; enzyme binding; kinase binding; proteasome core complex binding; protein antigen binding; protein binding; protein domain specific binding; serine-type endopeptidase activity; serine-type peptidase activity; signaling receptor binding
Biological Process:  blood coagulation; cellular protein metabolic process; extracellular matrix disassembly; fibrinolysis; interaction with symbiont; interaction with symbiont via secreted substance involved in symbiotic interaction; modification by host of symbiont morphology or physiology via secreted substance; negative regulation of cell proliferation; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of cell-substrate adhesion; negative regulation of fibrinolysis; platelet degranulation; positive regulation of fibrinolysis; proteolysis; tissue remodeling
Disease: Plasminogen Deficiency, Type I
Reference #:  P00747 (UniProtKB)
Alt. Names/Synonyms: Activation peptide; Angiostatin; DKFZp779M0222; plasmin; Plasmin heavy chain A; Plasmin heavy chain A, short form; Plasmin light chain B; Plasminogen; PLG; PLMN
Gene Symbols: PLG
Molecular weight: 90,569 Da
Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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