CD44 Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 2 E2|2 54.13 cM
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cell projection; cell surface; cytosol; external side of plasma membrane; Golgi apparatus; integral component of membrane; membrane; microvillus; nucleus; plasma membrane
Molecular Function:  cytokine binding; epidermal growth factor receptor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; hyaluronic acid binding; phosphoprotein binding; protein binding; protein kinase binding; transmembrane receptor activity; type II transforming growth factor beta receptor binding
Biological Process:  branching involved in ureteric bud morphogenesis; cell adhesion; cell migration; cell surface receptor signaling pathway; cellular response to fibroblast growth factor stimulus; healing during inflammatory response; hyaluronan catabolic process; inflammatory response; negative regulation of apoptosis; negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of inflammatory response; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of mature B cell apoptosis; negative regulation of regulatory T cell differentiation; neuron projection development; positive regulation of adaptive immune response; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of heterotypic cell-cell adhesion; positive regulation of kinase activity; positive regulation of monocyte aggregation; positive regulation of neutrophil apoptosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cell growth; regulation of lamellipodium morphogenesis; Wnt signaling pathway; wound healing, spreading of cells
Reference #:  P15379 (UniProtKB)
Alt. Names/Synonyms: AU023126; AW121933; AW146109; Cd44; CD44 antigen; ECMR-III; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HERMES; Hermes antigen; HUTCH-I; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; OTTMUSP00000015733; OTTMUSP00000015734; OTTMUSP00000015735; PGP-1; PGP-I; Phagocytic glycoprotein 1; Phagocytic glycoprotein I
Gene Symbols: Cd44
Molecular weight: 85,617 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene