5-HT(3) This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Cellular Component: 
Reference #:  O70212 (UniProtKB)
Alt. Names/Synonyms: 5-HT-3; 5-HT3R; 5-hydroxytryptamine 3 receptor; 5-hydroxytryptamine receptor 3A; 5HT3A; 5HT3R; HTR3; HTR3A; Serotonin-gated ion channel receptor
Gene Symbols: Htr3a
Molecular weight: 55,656 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
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5-HT(3)

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept