CD3G Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component:  clathrin-coated vesicle membrane; integral component of plasma membrane; plasma membrane; T cell receptor complex
Molecular Function:  protein heterodimerization activity; protein homodimerization activity; receptor signaling complex scaffold activity; T cell receptor binding; transmembrane signaling receptor activity
Biological Process:  adaptive immune response; cell surface receptor signaling pathway; establishment or maintenance of cell polarity; Fc-gamma receptor signaling pathway involved in phagocytosis; membrane organization; positive regulation of signal transduction; protein homooligomerization; protein transport; protein-containing complex assembly; regulation of immune response; regulation of lymphocyte apoptotic process; T cell activation; T cell receptor signaling pathway
Disease: Immunodeficiency 17
Reference #:  P09693 (UniProtKB)
Alt. Names/Synonyms: CD3-GAMMA; CD3G; CD3G antigen, gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, gamma (CD3-TCR complex); FLJ17620; FLJ17664; FLJ79544; FLJ94613; MGC138597; T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 gamma chain; T-cell surface glycoprotein CD3 gamma chain; T3G
Gene Symbols: CD3G
Molecular weight: 20,469 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
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Protein Structure Not Found.

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