DNAM-1 Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding. Expressed by peripheral blood T-lymphocytes. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18|18 E4
Cellular Component:  cell surface; external side of plasma membrane; integral component of membrane; membrane; plasma membrane
Molecular Function:  cell adhesion molecule binding; integrin binding; protein binding; protein kinase binding
Biological Process:  cell adhesion; cytokine production; positive regulation of Fc receptor mediated stimulatory signaling pathway; positive regulation of immunoglobulin mediated immune response; positive regulation of interferon-gamma production; positive regulation of mast cell activation; positive regulation of natural killer cell cytokine production; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of T cell receptor signaling pathway
Reference #:  Q8K4F0 (UniProtKB)
Alt. Names/Synonyms: BC051526; Cd226; CD226 antigen; DNA; DNAM; DNAM-1; DNAM1; OTTMUSP00000015835; OTTMUSP00000015836; platelet and T cell activation antigen 1; Platelet and T-cell activation antigen 1; Pta1; TLiSA1
Gene Symbols: Cd226
Molecular weight: 38,063 Da
Basal Isoelectric point: 9.19  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene