Claudin-1 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Acts as a co- receptor for HCV entry into hepatic cells. Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL. May interact with HCV E1 and E2 proteins. Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. Belongs to the claudin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3q28
Cellular Component:  apical plasma membrane; basolateral plasma membrane; bicellular tight junction; cytoplasm; integral component of membrane; integral component of plasma membrane; lateral plasma membrane
Molecular Function:  identical protein binding; protein binding; structural molecule activity; virus receptor activity
Biological Process:  aging; bicellular tight junction assembly; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; cell-cell junction organization; cellular response to butyrate; cellular response to interferon-gamma; cellular response to lead ion; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; drug transport across blood-nerve barrier; establishment of blood-nerve barrier; establishment of endothelial intestinal barrier; establishment of skin barrier; hyperosmotic salinity response; liver regeneration; positive regulation of bicellular tight junction assembly; protein heterooligomerization; protein homooligomerization; response to dexamethasone; response to ethanol; response to interleukin-18; response to lipopolysaccharide; viral entry into host cell
Disease: Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis
Reference #:  O95832 (UniProtKB)
Alt. Names/Synonyms: claudin 1; Claudin-1; claudin1; CLD1; CLDN1; ILVASC; SEMP1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1
Gene Symbols: CLDN1
Molecular weight: 22,744 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene