Claudin-1 Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. Acts as a receptor for dengue virus. Belongs to the claudin family. Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3q28
Cellular Component:  apical plasma membrane; basolateral plasma membrane; bicellular tight junction; cytoplasm; integral component of membrane; integral component of plasma membrane; lateral plasma membrane
Molecular Function:  identical protein binding; protein binding; structural molecule activity; virus receptor activity
Biological Process:  aging; bicellular tight junction assembly; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; cell-cell junction organization; cellular response to butyrate; cellular response to interferon-gamma; cellular response to lead ion; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; drug transport across blood-nerve barrier; establishment of blood-nerve barrier; establishment of endothelial intestinal barrier; establishment of skin barrier; hyperosmotic salinity response; liver regeneration; positive regulation of bicellular tight junction assembly; protein heterooligomerization; protein homooligomerization; response to dexamethasone; response to ethanol; response to interleukin-18; response to lipopolysaccharide; viral entry into host cell
Disease: Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis
Reference #:  O95832 (UniProtKB)
Alt. Names/Synonyms: claudin 1; Claudin-1; claudin1; CLD1; CLDN1; ILVASC; SEMP1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1
Gene Symbols: CLDN1
Molecular weight: 22,744 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene