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Claudin-1
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. Acts as a receptor for dengue virus. Belongs to the claudin family. Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of mouse Ortholog: 16|16 B2 |
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Cellular Component:
anchoring junction; apical plasma membrane; basolateral plasma membrane; bicellular tight junction; cell junction; cell-cell junction; lateral plasma membrane; membrane; plasma membrane; protein-containing complex; tight junction
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Molecular Function:
identical protein binding; protein binding; structural molecule activity; virus receptor activity
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Biological Process:
bicellular tight junction assembly; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; cell adhesion; cell junction maintenance; cell-cell junction organization; establishment of blood-nerve barrier; establishment of endothelial intestinal barrier; establishment of skin barrier; positive regulation of bicellular tight junction assembly; positive regulation of cell migration; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of wound healing; protein complex oligomerization; response to interleukin-18; xenobiotic transport across blood-nerve barrier
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Reference #:
O88551
(UniProtKB)
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Alt. Names/Synonyms: AI596271; claudin 1; Claudin-1; claudin1; CLD1; Cldn1; OTTMUSP00000025830
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Gene Symbols: Cldn1
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Molecular weight:
22,881 Da
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Basal Isoelectric point:
8.14
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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