CLCN3 Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily. Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle
Chromosomal Location of mouse Ortholog: 8 B3.1|8 30.9 cM
Cellular Component:  apical plasma membrane; axon terminus; cytoplasmic vesicle; early endosome; early endosome membrane; endosome; endosome membrane; external side of plasma membrane; GABA-ergic synapse; glutamatergic synapse; Golgi apparatus; inhibitory synapse; intracellular membrane-bounded organelle; late endosome; late endosome membrane; lysosomal membrane; lysosome; membrane; phagocytic vesicle; plasma membrane; postsynaptic membrane; recycling endosome; recycling endosome membrane; secretory granule; specific granule; synapse; synaptic vesicle; synaptic vesicle membrane; vesicle membrane
Molecular Function:  antiporter activity; ATP binding; chloride channel activity; monoatomic ion channel activity; nucleotide binding; PDZ domain binding; voltage-gated chloride channel activity; voltage-gated monoatomic ion channel activity; volume-sensitive chloride channel activity
Biological Process:  adult locomotory behavior; chloride transmembrane transport; chloride transport; monoatomic ion transport; negative regulation of cell volume; neuron cellular homeostasis; phagocytosis, engulfment; photoreceptor cell maintenance; positive regulation of reactive oxygen species biosynthetic process; synaptic transmission, GABAergic; synaptic transmission, glutamatergic; synaptic vesicle lumen acidification; transmembrane transport
Reference #:  P51791 (UniProtKB)
Alt. Names/Synonyms: chloride channel 3; Chloride channel protein 3; chloride channel, voltage-sensitive 3; Chloride transporter ClC-3; Clc; ClC-3; Clc3; Clcn3; H(+)/Cl(-) exchange transporter 3; OTTMUSP00000025333; OTTMUSP00000025335
Gene Symbols: Clcn3
Molecular weight: 90,812 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein