mAChR M5
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily. Note: This description may include information from UniProtKB.
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Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
Chromosomal Location of human Ortholog: 15q14 |
Cellular Component:
dendrite; plasma membrane; postsynaptic membrane; synapse
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Molecular Function:
G protein-coupled acetylcholine receptor activity; G protein-coupled serotonin receptor activity; phosphatidylinositol phospholipase C activity; protein binding
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Biological Process:
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; chemical synaptic transmission; dopamine transport; G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G protein-coupled serotonin receptor signaling pathway; gastric acid secretion; regulation of phosphatidylinositol dephosphorylation; transmission of nerve impulse
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Reference #:
P08912
(UniProtKB)
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Alt. Names/Synonyms: acetylcholine receptor, muscarinic 5; ACM5; cholinergic receptor muscarinic 5; cholinergic receptor, muscarinic 5; CHRM5; HM5; mAChR M5; MGC41838; Muscarinic acetylcholine receptor M5
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Gene Symbols: CHRM5
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Molecular weight:
60,074 Da
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Basal Isoelectric point:
9.39
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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