CLCN3 Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle
Chromosomal Location of Human Ortholog: 4q33
Cellular Component:  cell surface; cytoplasmic vesicle; early endosome; early endosome membrane; endosome; external side of plasma membrane; Golgi apparatus; Golgi membrane; integral component of membrane; integral component of plasma membrane; late endosome; late endosome membrane; phagocytic vesicle; plasma membrane; secretory granule; specific granule; synaptic vesicle; vesicle membrane
Molecular Function:  antiporter activity; ATP binding; chloride channel activity; chloride ion binding; PDZ domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity; solute:proton antiporter activity; voltage-gated chloride channel activity; volume-sensitive chloride channel activity
Biological Process:  endosomal lumen acidification; negative regulation of cell volume; regulation of pH
Reference #:  P51790 (UniProtKB)
Alt. Names/Synonyms: chloride channel 3; Chloride channel protein 3; Chloride transporter ClC-3; ClC-3; CLC3; CLCN3; H(+)/Cl(-) exchange transporter 3
Gene Symbols: CLCN3
Molecular weight: 90,966 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CLCN3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein