SPPL2A Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis. Belongs to the peptidase A22B family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease
Chromosomal Location of mouse Ortholog: 2|2 F1
Cellular Component:  endosome; Golgi-associated vesicle membrane; integral component of cytoplasmic side of endoplasmic reticulum membrane; integral component of lumenal side of endoplasmic reticulum membrane; integral component of membrane; intracellular membrane-bounded organelle; late endosome; late endosome membrane; lysosomal membrane; lysosome; membrane; plasma membrane
Molecular Function:  aspartic endopeptidase activity, intramembrane cleaving; aspartic-type endopeptidase activity; hydrolase activity; peptidase activity; protein homodimerization activity
Biological Process:  membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; membrane protein proteolysis; proteolysis; regulation of immune response
Reference #:  Q9JJF9 (UniProtKB)
Alt. Names/Synonyms: 2010106G01Rik; C130089K23Rik; CT98; IMP-3; Imp3; Intramembrane protease 3; OTTMUSP00000017031; Presenilin-like protein 2; protein SPPL2a; Psl2; RIKEN cDNA 2010106G01 gene; signal peptide peptidase like 2A; Signal peptide peptidase-like 2A; SPP-like 2A; SPP-like 2A protein; SPP2A; SPPL2a
Gene Symbols: Sppl2a
Molecular weight: 58,129 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene