SPPL2A Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis. Belongs to the peptidase A22B family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease
Chromosomal Location of human Ortholog: 15q21.2
Cellular Component:  Golgi-associated vesicle membrane; integral component of cytoplasmic side of endoplasmic reticulum membrane; integral component of lumenal side of endoplasmic reticulum membrane; intracellular membrane-bounded organelle; late endosome; late endosome membrane; membrane; plasma membrane
Molecular Function:  aspartic endopeptidase activity, intramembrane cleaving; protein binding; protein homodimerization activity
Biological Process:  membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; membrane protein proteolysis; regulation of immune response; regulation of tumor necrosis factor-mediated signaling pathway
Disease: Immunodeficiency 86
Reference #:  Q8TCT8 (UniProtKB)
Alt. Names/Synonyms: CT98; IMP-3; IMP3; intramembrane cleaving protease; Intramembrane protease 3; Presenilin-like protein 2; PSL2; signal peptide peptidase like 2A; Signal peptide peptidase-like 2A; SPP-like 2A; SPP2A; SPPL2A
Gene Symbols: SPPL2A
Molecular weight: 58,143 Da
Basal Isoelectric point: 8.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB