RASA3 Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of Human Ortholog: 13q34
Cellular Component:  cytosol; intrinsic component of the cytoplasmic side of the plasma membrane
Molecular Function:  calcium-release channel activity; GTPase activator activity; metal ion binding
Biological Process:  MAPK cascade; negative regulation of Ras protein signal transduction; positive regulation of GTPase activity; release of sequestered calcium ion into cytosol; signal transduction
Reference #:  Q14644 (UniProtKB)
Alt. Names/Synonyms: GAP1(IP4BP); GAP1IP4BP; GAPIII; GTPase activating protein III; GTPase-activating protein 1 family, inositol 1,3,4,5-tetrakisphosphate-binding protein; inositol 1,3,4,5-tetrakisphosphate-binding protein; Ins P4-binding protein; Ins(1,3,4,5)P4-binding protein; MGC46517; MGC47588; Ras GTPase-activating protein 3; RAS p21 protein activator 3; RASA3; RasGAP 3
Gene Symbols: RASA3
Molecular weight: 95,699 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  T Cell Receptor Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene