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RASA3
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Ras |
| Chromosomal Location of Human Ortholog: 13q34 |
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Cellular Component:
cytosol; intrinsic component of the cytoplasmic side of the plasma membrane
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Molecular Function:
calcium-release channel activity; GTPase activator activity; metal ion binding
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Biological Process:
MAPK cascade; negative regulation of Ras protein signal transduction; positive regulation of GTPase activity; release of sequestered calcium ion into cytosol; signal transduction
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Reference #:
Q14644
(UniProtKB)
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Alt. Names/Synonyms: GAP1(IP4BP); GAP1IP4BP; GAPIII; GTPase activating protein III; GTPase-activating protein 1 family, inositol 1,3,4,5-tetrakisphosphate-binding protein; inositol 1,3,4,5-tetrakisphosphate-binding protein; Ins P4-binding protein; Ins(1,3,4,5)P4-binding protein; MGC46517; MGC47588; Ras GTPase-activating protein 3; RAS p21 protein activator 3; RASA3; RasGAP 3
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Gene Symbols: RASA3
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Molecular weight:
95,699 Da
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Basal Isoelectric point:
6.76
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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GPCR Signaling to MAPKs
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T Cell Receptor Signaling
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