PTPRN2 iso4 Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization. Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate. Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. Highest levels in brain and pancreas (PubMed:8954911, PubMed:8798755). Lower levels in trachea, prostate, stomach and spinal chord (PubMed:8798755). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 7q36.3
Cellular Component:  cell junction; endoplasmic reticulum lumen; ficolin-1-rich granule membrane; integral component of plasma membrane; integral component of synaptic vesicle membrane; plasma membrane; receptor complex; secretory granule membrane; synaptic vesicle membrane; terminal bouton
Molecular Function:  transmembrane receptor protein tyrosine phosphatase activity
Biological Process:  insulin secretion involved in cellular response to glucose stimulus; lipid metabolic process; negative regulation of GTPase activity; neurotransmitter secretion; neutrophil degranulation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation
Reference #:  Q92932-4 (UniProtKB)
Alt. Names/Synonyms: IAR; ICAAR; Islet cell autoantigen-related protein; KIAA0387; PTPRN2; PTPRN2 iso4; R-PTP-N2; Receptor-type tyrosine-protein phosphatase N2
Gene Symbols: PTPRN2
Molecular weight: 109,622 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
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PTPRN2 iso4

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein