PLM Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Belongs to the FXYD family. Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Channel, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q21
Cellular Component:  apical plasma membrane; caveola; integral component of membrane; intercalated disc; plasma membrane; sarcolemma; sodium:potassium-exchanging ATPase complex; T-tubule
Molecular Function:  ATPase binding; ion channel regulator activity; myosin binding; protein binding; sodium channel regulator activity
Biological Process:  brain development; ion transport; negative regulation of protein glutathionylation; positive regulation of inorganic anion transmembrane transport; positive regulation of organic acid transport; positive regulation of sodium ion export across plasma membrane; potassium ion transport; regulation of cardiac muscle cell contraction; regulation of cardiac muscle cell membrane potential; regulation of cytosolic calcium ion concentration; regulation of sodium ion transmembrane transporter activity; regulation of sodium:potassium-exchanging ATPase activity; sodium ion transport
Reference #:  O08589 (UniProtKB)
Alt. Names/Synonyms: FXYD domain-containing ion transport regulator 1; Fxyd1; Phospholemman; Plm
Gene Symbols: Fxyd1
Molecular weight: 10,365 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene