SREC-II Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Defects in SCARF2 are the cause of Van den Ende-Gupta syndrome (VDEGS). A syndrome characterized by craniofacial and skeletal abnormalities that include blepharophimosis, a flat and wide nasal bridge, narrow and beaked nose, hypoplastic maxilla with or without cleft palate and everted lower lip, prominent ears, down-slanting eyes, arachnodactyly, and camptodactyly. Patients present congenital joint contractures that improve without intervention, and normal growth and development. Intelligence is normal. Rarely, enlarged cerebella can be present. Some patients experience respiratory problems due to laryngeal abnormalities. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component:  integral component of membrane
Molecular Function:  protein binding
Biological Process:  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Disease: Van Den Ende-gupta Syndrome
Reference #:  Q96GP6 (UniProtKB)
Alt. Names/Synonyms: NSR1; SCARF2; Scavenger receptor class F member 2; scavenger receptor class F, member 2; Scavenger receptor expressed by endothelial cells 2 protein; SREC-II; SREC2; SRECRP-1; SREPCR
Gene Symbols: SCARF2
Molecular weight: 92,384 Da
Basal Isoelectric point: 8.77  Predict pI for various phosphorylation states
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SREC-II

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB