MKK3 iso3 Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of human Ortholog: 17p11.2
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  ATP binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity
Biological Process:  cardiac muscle contraction; cellular response to lipopolysaccharide; cellular response to sorbitol; cellular response to vascular endothelial growth factor stimulus; cellular senescence; heart development; inflammatory response; MAPK cascade; negative regulation of hippo signaling; p38MAPK cascade; peptidyl-tyrosine phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of DNA-templated transcription; positive regulation of MAPK cascade; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of protein kinase activity; regulation of cytokine production; response to ischemia; signal transduction
Reference #:  P46734-3 (UniProtKB)
Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAP2K3; MAPK/ERK kinase 3; MAPKK 3; MAPKK3; MEK 3; MEK3; mitogen-activated protein kinase kinase 3; MKK3; MKK3 iso3; MP2K3; PRKMK3; SAPK kinase 2; SAPKK-2; SAPKK2; SKK2; Stress-activated protein kinase kinase 2
Gene Symbols: MAP2K3
Molecular weight: 39,940 Da
Basal Isoelectric point: 7.08  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Regulation of P38 MAPKs  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
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MKK3 iso3

Protein Structure Not Found.

Cross-references to other databases:  Protein Atlas  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene