basonuclin 1
Transcriptional activator. Likely specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. Required for the maintenance of spermatogenesis. May also play a role in the differentiation of oocytes and the early development of embryos. In epidermis, primarily detected in cells of the basal or immediately suprabasal layers (at protein level) (PubMed:16891417). In hair follicles, mainly expressed in the outer root sheath (at protein level) (PubMed:8034748). Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart (PubMed:9687312). Note: This description may include information from UniProtKB.
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Protein type: C2H2-type zinc finger protein; Transcription factor |
Chromosomal Location of human Ortholog: 15q25.2 |
Cellular Component:
cytoplasm; nucleolus; nucleoplasm; nucleus
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Molecular Function:
DNA-binding transcription activator activity; metal ion binding; rDNA binding
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Biological Process:
cell differentiation; epidermis development; positive regulation of cell population proliferation; positive regulation of oocyte maturation; positive regulation of transcription by RNA polymerase I; regulation of transcription by RNA polymerase I; spermatogenesis
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Disease: Premature Ovarian Failure 16
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Reference #:
Q01954
(UniProtKB)
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Alt. Names/Synonyms: basonuclin 1; BNC; BNC1; BSN1; HsT19447; POF16; zinc finger protein basonuclin; Zinc finger protein basonuclin-1
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Gene Symbols: BNC1
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Molecular weight:
110,972 Da
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Basal Isoelectric point:
7
Predict pI for various phosphorylation states
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