basonuclin 1 Transcriptional activator. Likely specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. Required for the maintenance of spermatogenesis. May also play a role in the differentiation of oocytes and the early development of embryos. In epidermis, primarily detected in cells of the basal or immediately suprabasal layers (at protein level) (PubMed:16891417). In hair follicles, mainly expressed in the outer root sheath (at protein level) (PubMed:8034748). Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart (PubMed:9687312). Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor
Chromosomal Location of human Ortholog: 15q25.2
Cellular Component:  cytoplasm; nucleolus; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription activator activity; metal ion binding; rDNA binding
Biological Process:  cell differentiation; epidermis development; positive regulation of cell population proliferation; positive regulation of oocyte maturation; positive regulation of transcription by RNA polymerase I; regulation of transcription by RNA polymerase I; spermatogenesis
Disease: Premature Ovarian Failure 16
Reference #:  Q01954 (UniProtKB)
Alt. Names/Synonyms: basonuclin 1; BNC; BNC1; BSN1; HsT19447; POF16; zinc finger protein basonuclin; Zinc finger protein basonuclin-1
Gene Symbols: BNC1
Molecular weight: 110,972 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below

basonuclin 1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein