CTNND1 iso12
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway. Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. Belongs to the beta-catenin family. Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs. 32 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 11q12.1 |
Cellular Component:
adherens junction; catenin complex; cell surface; cell-cell junction; cytoplasm; cytosol; dendritic spine; glutamatergic synapse; growth cone; hippocampal mossy fiber to CA3 synapse; lamellipodium; midbody; nucleus; plasma membrane; postsynaptic density, intracellular component; presynaptic active zone cytoplasmic component; Schaffer collateral - CA1 synapse; zonula adherens
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Molecular Function:
beta-catenin binding; cadherin binding; protein binding; protein tyrosine kinase binding; signaling receptor binding
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Biological Process:
cell-cell adhesion; cell-cell adhesion mediated by cadherin; cell-cell junction assembly; cytoplasmic sequestering of protein; negative regulation of canonical Wnt signaling pathway; protein stabilization; regulation of postsynaptic membrane neurotransmitter receptor levels; Wnt signaling pathway
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Reference #:
O60716-12
(UniProtKB)
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Alt. Names/Synonyms: BCDS2; Cadherin-associated Src substrate; CAS; catenin (cadherin-associated protein), delta 1; catenin delta 1; Catenin delta-1; CTND1; CTNND; CTNND1; CTNND1 iso12; KIAA0384; p120; p120 catenin; p120(cas); p120(ctn); P120CAS; P120CTN
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Gene Symbols: CTNND1
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Molecular weight:
99,673 Da
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Basal Isoelectric point:
6.06
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Wnt/ß-Catenin Signaling
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