Rhodopsin Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. Rod shaped photoreceptor cells which mediate vision in dim light. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Cellular Component:  cell-cell junction; G protein-coupled receptor complex; Golgi membrane; integral component of membrane; integral component of plasma membrane; outer membrane; photoreceptor disc membrane; photoreceptor inner segment membrane; photoreceptor outer segment membrane; plasma membrane
Molecular Function:  11-cis retinal binding; arrestin family protein binding; G protein-coupled photoreceptor activity; G-protein alpha-subunit binding; guanyl-nucleotide exchange factor activity; identical protein binding; opsin binding; protein binding; zinc ion binding
Biological Process:  absorption of visible light; photoreceptor cell maintenance; phototransduction, visible light; protein phosphorylation; protein-chromophore linkage; response to light stimulus; retina development in camera-type eye; rhodopsin mediated signaling pathway; visual perception
Reference #:  P02699 (UniProtKB)
Alt. Names/Synonyms: BOS_21149; OPSD; RHO; Rhodopsin
Gene Symbols: RHO
Molecular weight: 39,008 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene