| Rhodopsin Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. Rod shaped photoreceptor cells which mediate vision in dim light. Note: This description may include information from UniProtKB. |
| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Cellular Component: cell-cell junction; G protein-coupled receptor complex; Golgi membrane; membrane; outer membrane; photoreceptor disc membrane; photoreceptor inner segment membrane; photoreceptor outer segment membrane; plasma membrane; rod photoreceptor outer segment; sperm head plasma membrane; sperm midpiece |
| Molecular Function: 11-cis retinal binding; arrestin family protein binding; G protein-coupled photoreceptor activity; G-protein alpha-subunit binding; guanyl-nucleotide exchange factor activity; identical protein binding; opsin binding; protein binding; zinc ion binding |
| Biological Process: absorption of visible light; detection of temperature stimulus involved in thermoception; photoreceptor cell maintenance; phototransduction, visible light; protein phosphorylation; response to light stimulus; retina development in camera-type eye; rhodopsin mediated signaling pathway; thermotaxis; visual perception |
| Reference #: P02699 (UniProtKB) |
| Alt. Names/Synonyms: BOS_21149; OPSD; RHO; Rhodopsin |
| Gene Symbols: RHO |
| Molecular weight: 39,008 Da |
| Basal Isoelectric point: 5.87 Predict pI for various phosphorylation states |
| Select Structure to View Below |
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Rhodopsin |
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| Cross-references to other databases:
AlphaFold
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STRING
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Pfam
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