RB1CC1
Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis. Belongs to the ATG17 family. Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Autophagy; DNA-binding; Transcription factor; Tumor suppressor |
Chromosomal Location of mouse Ortholog: 1|1 A1 |
Cellular Component:
Atg1/ULK1 kinase complex; autophagosome membrane; cytoplasm; cytosol; lysosome; nuclear membrane; nucleus; phagophore assembly site; phagophore assembly site membrane
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Molecular Function:
molecular adaptor activity; protein binding; protein kinase binding
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Biological Process:
apoptotic process; autophagosome assembly; autophagy; autophagy of mitochondrion; autophagy of peroxisome; cell cycle; extrinsic apoptotic signaling pathway; glycophagy; heart development; liver development; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of extrinsic apoptotic signaling pathway; piecemeal microautophagy of the nucleus; positive regulation of autophagy; positive regulation of cell size; positive regulation of JNK cascade; positive regulation of protein phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of protein lipidation; reticulophagy
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Reference #:
Q9ESK9
(UniProtKB)
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Alt. Names/Synonyms: 200 kDa FAK family kinase-interacting protein; 2900055E04Rik; 5930404L04Rik; Cc1; coiled coil forming protein 1; Coiled-coil-forming protein 1; FAK family kinase-interacting protein of 200 kDa; Fip2; FIP200; Kiaa0203; LaXp; LaXp180; RB1-inducible coiled-coil 1; RB1-inducible coiled-coil protein 1; Rb1cc1; RBCC1
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Gene Symbols: Rb1cc1
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Molecular weight:
182,350 Da
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Basal Isoelectric point:
5.35
Predict pI for various phosphorylation states
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CST Pathways:
Autophagy Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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