RB1CC1 Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis. Belongs to the ATG17 family. Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy; DNA-binding; Transcription factor; Tumor suppressor
Chromosomal Location of Human Ortholog: 1|1 A1
Cellular Component:  Atg1/ULK1 kinase complex; cytoplasm; cytosol; extrinsic component of membrane; lysosome; nuclear membrane; nucleus; phagophore assembly site; phagophore assembly site membrane
Molecular Function:  protein binding; protein kinase binding
Biological Process:  autophagosome assembly; autophagy; autophagy of mitochondrion; autophagy of peroxisome; cell cycle; glycophagy; heart development; liver development; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; piecemeal microautophagy of the nucleus; positive regulation of cell size; positive regulation of JNK cascade; positive regulation of protein phosphorylation; reticulophagy
Reference #:  Q9ESK9 (UniProtKB)
Alt. Names/Synonyms: 200 kDa FAK family kinase-interacting protein; 2900055E04Rik; 5930404L04Rik; Cc1; coiled coil forming protein 1; Coiled-coil-forming protein 1; FIP200; Kiaa0203; LaXp180; RB1-inducible coiled-coil 1; RB1-inducible coiled-coil protein 1; Rb1cc1; RBCC1
Gene Symbols: Rb1cc1
Molecular weight: 182,350 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RB1CC1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene