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LANP-L iso3
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. Belongs to the ANP32 family. Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Vesicle |
| Chromosomal Location of human Ortholog: 1q21.2 |
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Cellular Component:
cytoplasmic vesicle; nucleus; Swr1 complex
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Molecular Function:
histone binding; histone chaperone activity; phosphatase inhibitor activity; protein binding; protein folding chaperone
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Biological Process:
chromatin organization; protein folding; regulation of apoptotic process
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Reference #:
Q9BTT0-3
(UniProtKB)
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Alt. Names/Synonyms: acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; Acidic leucine-rich nuclear phosphoprotein 32 family member E; acidic nuclear phosphoprotein 32 family member E; AN32E; ANP32E; LANP-L; LANP-L iso3; LANP-like protein; LANPL; leucine-rich acidic nuclear protein like
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Gene Symbols: ANP32E
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Molecular weight:
25,125 Da
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Basal Isoelectric point:
3.65
Predict pI for various phosphorylation states
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