KIDINS220 Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 6q16
Cellular Component:  cytosol; integral component of membrane; late endosome; protein-containing complex
Molecular Function:  PDZ domain binding; protein binding; protein kinase binding; protein kinase regulator activity
Biological Process:  cellular response to nerve growth factor stimulus; dendrite morphogenesis; in utero embryonic development; nerve growth factor signaling pathway; positive regulation of neuron projection development; regulation of protein kinase activity
Reference #:  Q9EQG6 (UniProtKB)
Alt. Names/Synonyms: ankyrin repeat-rich membrane spanning protein; Ankyrin repeat-rich membrane-spanning protein; Arms; KDIS; Kidins220; kinase D-interacting substance 220; kinase D-interacting substance of 220 kDa; kinase D-interacting substrate 220; Kinase D-interacting substrate of 220 kDa
Gene Symbols: Kidins220
Molecular weight: 195,716 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene