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PTRF
Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template. The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A. Belongs to the CAVIN family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription initiation complex |
| Chromosomal Location of human Ortholog: 17q21.2 |
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Cellular Component:
caveola; cytoplasm; cytosol; endoplasmic reticulum; intracellular membrane-bounded organelle; membrane raft; mitochondrion; nucleoplasm; nucleus; plasma membrane; protein-containing complex
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Molecular Function:
identical protein binding; protein binding; rRNA primary transcript binding
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Biological Process:
positive regulation of cell motility; protein secretion; rRNA transcription; termination of RNA polymerase I transcription; transcription initiation at RNA polymerase I promoter
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Disease: Lipodystrophy, Congenital Generalized, Type 4
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Reference #:
Q6NZI2
(UniProtKB)
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Alt. Names/Synonyms: caveolae associated protein 1; Caveolae-associated protein 1; CAVIN; Cavin-1; CAVIN1; CAVN1; CGL4; congenital generalized lipodystrophy 4; FKSG13; FLJ90031; Polymerase I and transcript release factor; PTRF; RNA polymerase I and transcript release factor; TTF-I interacting peptide 12
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Gene Symbols: CAVIN1
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Molecular weight:
43,476 Da
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Basal Isoelectric point:
5.51
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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