PRM2
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. Belongs to the protamine P2 family. Testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cancer Testis Antigen (CTA); DNA-binding |
Chromosomal Location of human Ortholog: 16p13.13 |
Cellular Component:
male germ cell nucleus; nucleoplasm; nucleosome; nucleus
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Molecular Function:
cadmium ion binding; DNA binding; protein binding; zinc ion binding
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Biological Process:
chromosome condensation; chromosome organization; nucleus organization; spermatid development; spermatogenesis
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Reference #:
P04554
(UniProtKB)
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Alt. Names/Synonyms: Basic nuclear protein HPI1; Basic nuclear protein HPI2; Basic nuclear protein HPS1; Basic nuclear protein HPS2; cancer/testis antigen family 94, member 2; CT94.2; FLJ27447; P2'; P2''; PRM2; Protamine 2; Protamine-2; Sperm histone HP2; Sperm histone HP3; Sperm histone HP4; Sperm histone P2; Sperm protamine P2; Sperm protamine P3; Sperm protamine P4; testicular secretory protein Li 40
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Gene Symbols: PRM2
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Molecular weight:
13,051 Da
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Basal Isoelectric point:
11.9
Predict pI for various phosphorylation states
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