PRM2 Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. Belongs to the protamine P2 family. Testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); DNA-binding
Chromosomal Location of human Ortholog: 16p13.13
Cellular Component:  male germ cell nucleus; nucleoplasm; nucleosome; nucleus
Molecular Function:  cadmium ion binding; DNA binding; protein binding; zinc ion binding
Biological Process:  chromosome condensation; chromosome organization; nucleus organization; spermatid development; spermatogenesis
Reference #:  P04554 (UniProtKB)
Alt. Names/Synonyms: Basic nuclear protein HPI1; Basic nuclear protein HPI2; Basic nuclear protein HPS1; Basic nuclear protein HPS2; cancer/testis antigen family 94, member 2; CT94.2; FLJ27447; P2'; P2''; PRM2; Protamine 2; Protamine-2; Sperm histone HP2; Sperm histone HP3; Sperm histone HP4; Sperm histone P2; Sperm protamine P2; Sperm protamine P3; Sperm protamine P4; testicular secretory protein Li 40
Gene Symbols: PRM2
Molecular weight: 13,051 Da
Basal Isoelectric point: 11.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein