Ikaros iso2 Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs). Function is isoform-specific and is modulated by dominant-negative inactive isoforms. Belongs to the Ikaros C2H2-type zinc-finger protein family. Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 7p12.2
Cellular Component:  cytoplasm; nuclear pericentric heterochromatin; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; protein domain specific binding
Biological Process:  cell cycle; chromatin organization; erythrocyte differentiation; lymphocyte differentiation; mesoderm development; negative regulation of transcription, DNA-templated; protein heterooligomerization
Reference #:  Q13422-2 (UniProtKB)
Alt. Names/Synonyms: CLL-associated antigen KW-6; CVID13; DNA-binding protein Ikaros; Hs.54452; IK1; IKAROS; IKAROS family zinc finger 1; Ikaros family zinc finger protein 1; Ikaros iso2; IKZF1; LyF-1; LYF1; Lymphoid transcription factor LyF-1; PPP1R92; PRO0758; protein phosphatase 1, regulatory subunit 92; zinc finger protein, subfamily 1A, 1 (Ikaros); ZNFN1A1
Gene Symbols: IKZF1
Molecular weight: 48,289 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Ikaros iso2

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein