factor V Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. Belongs to the multicopper oxidase family. Plasma. Note: This description may include information from UniProtKB.
Protein type: Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q24.2
Cellular Component:  COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment membrane; extracellular region; extracellular space; Golgi membrane; plasma membrane; platelet alpha granule lumen
Molecular Function:  copper ion binding; protein binding
Biological Process:  blood circulation; blood coagulation; cellular protein metabolic process; COPII vesicle coating; ER to Golgi vesicle-mediated transport; platelet degranulation; post-translational protein modification
Disease: Budd-chiari Syndrome; Factor V Deficiency; Pregnancy Loss, Recurrent, Susceptibility To, 1; Stroke, Ischemic; Thrombophilia Due To Activated Protein C Resistance
Reference #:  P12259 (UniProtKB)
Alt. Names/Synonyms: Activated protein C cofactor; Coagulation factor V; coagulation factor V (proaccelerin, labile factor); Coagulation factor V heavy chain; coagulation factor V jinjiang A2 domain; Coagulation factor V light chain; F5; FA5; factor V; factor V Leiden; FVL; PCCF; Proaccelerin, labile factor; RPRGL1; THPH2
Gene Symbols: F5
Molecular weight: 251,703 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
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factor V

Protein Structure Not Found.

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