factor V
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. Belongs to the multicopper oxidase family. Plasma. Note: This description may include information from UniProtKB.
Protein type: Protease; Secreted; Secreted, signal peptideChromosomal Location of human Ortholog: 1q24.2
Cellular Component:
COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment membrane; extracellular region; extracellular space; plasma membrane; platelet alpha granule; platelet alpha granule lumen
Molecular Function:
copper ion binding; protein binding
Biological Process:
blood circulation; blood coagulation; response to vitamin K
Disease: Budd-chiari Syndrome ; Factor V Deficiency ; Pregnancy Loss, Recurrent, Susceptibility To, 1 ; Stroke, Ischemic ; Thrombophilia Due To Activated Protein C Resistance
Reference #:
P12259
(UniProtKB)
Alt. Names/Synonyms: Activated protein C cofactor; Coagulation factor V; coagulation factor V (proaccelerin, labile factor); Coagulation factor V heavy chain; coagulation factor V jinjiang A2 domain; Coagulation factor V light chain; F5; FA5; factor V; factor V Leiden; FVL; PCCF; Proaccelerin, labile factor; RPRGL1; THPH2
Gene Symbols: F5
Molecular weight:
251,703 Da
Basal Isoelectric point:
5.68
Predict pI for various phosphorylation states
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factor V
1CZS - A=2065-2224 (human)
1CZT - A=2065-2224 (human)
1CZV - A/B=2065-2224 (human)
1FV4 - H=29-691, L=1574-2224 (human)
1Y61 - H=29-737, L=1574-2224 (human)
3P6Z - C/I=685-737 (human)
3P70 - M/N/O/P=685-737 (human)
3S9C - B=1561-1574 (human)
7KVE - B=29-2224 (human)
7KVF - B=29-2224 (human)
7KXY - A=29-737, B=1574-2224 (human)
7TPP - E=44-622 (human)
7TPQ - C=29-737, D=1574-2224 (human)
8FDG - A=29-2224 (human)
8TN9 - A=29-2224 (human)
