SLC4A1 Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. Belongs to the anion exchanger (TC 2.A.31) family. Detected in erythrocytes (at protein level) (PubMed:7506871, PubMed:26542571). Isoform 2 is expressed in kidney (at protein level) (PubMed:7506871). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component:  basolateral plasma membrane; cortical cytoskeleton; cytoplasmic side of plasma membrane; integral component of membrane; integral component of plasma membrane; plasma membrane; Z disc
Molecular Function:  anion transmembrane transporter activity; anion:anion antiporter activity; ankyrin binding; bicarbonate transmembrane transporter activity; chloride transmembrane transporter activity; hemoglobin binding; inorganic anion exchanger activity; protein binding; protein homodimerization activity; protein membrane anchor
Biological Process:  anion transport; bicarbonate transport; blood coagulation; cellular ion homeostasis; chloride transmembrane transport; chloride transport; erythrocyte development; glycolytic process; negative regulation of urine volume; pH elevation; phospholipid scrambling; protein localization to plasma membrane
Disease: Blood Group--diego System; Blood Group--froese; Blood Group--swann System; Blood Group--waldner Type; Blood Group--wright Antigen; Cryohydrocytosis; Malaria, Susceptibility To; Ovalocytosis, Southeast Asian; Renal Tubular Acidosis, Distal, Autosomal Dominant; Renal Tubular Acidosis, Distal, With Hemolytic Anemia; Spherocytosis, Type 4
Reference #:  P02730 (UniProtKB)
Alt. Names/Synonyms: AE 1; AE1; Anion exchange protein 1; Anion exchanger 1; anion exchanger-1; B3AT; band 3 anion exchanger; Band 3 anion transport protein; BND3; CD233; CHC; DI; Diego blood group; EMPB3; EPB3; erythrocyte membrane protein band 3; erythroid anion exchange protein; FR; Froese blood group; MGC116750; MGC116753; MGC126619; MGC126623; RTA1A; SAO; SLC4A1; solute carrier family 4 (anion exchanger), member 1 (Diego blood group); Solute carrier family 4 member 1; solute carrier family 4 member 1 (Diego blood group); solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); solute carrier family 4, anion exchanger, number 1; SPH4; SW; Swann blood group; Waldner blood group; WD; WD1; WR; Wright blood group
Gene Symbols: SLC4A1
Molecular weight: 101,792 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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