SLC4A1
Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. Belongs to the anion exchanger (TC 2.A.31) family. Detected in erythrocytes (at protein level) (PubMed:7506871, PubMed:26542571). Isoform 2 is expressed in kidney (at protein level) (PubMed:7506871). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
Chromosomal Location of human Ortholog: 17q21.31 |
Cellular Component:
ankyrin-1 complex; basolateral plasma membrane; cortical cytoskeleton; cytoplasmic side of plasma membrane; membrane; plasma membrane; Z disc
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Molecular Function:
ankyrin binding; bicarbonate transmembrane transporter activity; chloride transmembrane transporter activity; chloride:bicarbonate antiporter activity; hemoglobin binding; monoatomic anion transmembrane transporter activity; protein binding; protein homodimerization activity; protein-membrane adaptor activity; solute:inorganic anion antiporter activity
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Biological Process:
bicarbonate transport; blood coagulation; chloride transmembrane transport; chloride transport; erythrocyte development; intracellular monoatomic ion homeostasis; monoatomic anion transport; negative regulation of glycolytic process through fructose-6-phosphate; negative regulation of oxidoreductase activity; negative regulation of urine volume; pH elevation; plasma membrane phospholipid scrambling; protein localization to plasma membrane; regulation of intracellular pH; transmembrane transport
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Disease: Blood Group--diego System; Blood Group--froese; Blood Group--swann System; Blood Group--waldner Type; Blood Group--wright Antigen; Cryohydrocytosis; Malaria, Susceptibility To; Ovalocytosis, Southeast Asian; Renal Tubular Acidosis, Distal, Autosomal Dominant; Renal Tubular Acidosis, Distal, With Hemolytic Anemia; Spherocytosis, Type 4
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Reference #:
P02730
(UniProtKB)
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Alt. Names/Synonyms: AE 1; AE1; Anion exchange protein 1; Anion exchanger 1; anion exchanger-1; B3AT; band 3 anion exchanger; Band 3 anion transport protein; BND3; CD233; CHC; DI; Diego blood group; EMPB3; EPB3; erythrocyte membrane protein band 3; erythroid anion exchange protein; FR; Froese blood group; MGC116750; MGC116753; MGC126619; MGC126623; RTA1A; SAO; SLC4A1; solute carrier family 4 (anion exchanger), member 1 (Diego blood group); Solute carrier family 4 member 1; solute carrier family 4 member 1 (Diego blood group); solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); solute carrier family 4, anion exchanger, number 1; SPH4; SW; Swann blood group; Waldner blood group; WD; WD1; WR; Wright blood group
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Gene Symbols: SLC4A1
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Molecular weight:
101,792 Da
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Basal Isoelectric point:
5.08
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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